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Zhou et al. reveal that Pif1 can efficiently unfold any G-quadruplexes that it encounters as it patrols single-stranded DNA.
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Here, we used a novel fMRI Repetition Suppression (RS) design to test the hypotheses that action planning unfolds more efficiently for successive actions made with the same hand.
Therefore, it would seem reasonable to presume that intracellular proteins which exist in their native soluble forms even under stress conditions have an intrinsic ability to remain efficiently folded compared to proteins that unfold or aggregate under the same stresses.
Under these assumptions we show that using the technique of unfolding is possible to efficiently design a maximally permissive supervisor to solve this control problem.
A novel two-stage "unfolding" boot-up process efficiently configures the SpiNNaker hardware and loads the application using a high-speed flood-fill technique with support for run-time reconfiguration.
Summing up, surfactant oxyC8 causes a stronger and more long-term unfolding and maintains aggregation state more efficiently.
This experiment showed clearly that chromosomes depleted of Ki-67 efficiently regain their normal morphology after two rounds of unfolding and refolding.
This procedure allows us to efficiently generate stochastic realizations of replication, translation, and other reactions unfolding in a single infected cell, based on a system of equations that describes each essential reaction in the poliovirus life cycle.
A combination of time-resolved NMR and simulation deliver a glimpse into how proteins can so efficiently move within the ensemble of the native conformations while avoiding unfolding during that journey.
Its preposterous narrative, efficiently rendered by the blue-chip screenwriting team of Akiva Goldsman and David Koepp, unfolds with the locomotive elegance of a Tintin comic or an episode of "Murder, She Wrote".
In order to efficiently develop drugs according to this strategy, elucidation of the detailed molecular mechanism of the unfolding of the Aβ central helix is needed.
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