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To determine whether topically applied ESBA105, a single-chain antibody fragment against tumor necrosis factor (TNF -α, could efficienTNF -αnetrate into the anterior couldefficientlyuman eye.
Being a tenth of the molecular weight of mAbs and having high binding affinity and specificity, VHHs efficiently penetrate throughout the tumour mass and are retained at the tumour.
Our findings provide the most detailed structural understanding of periplasmic flagella and the surrounding cell envelope, which enable this enigmatic bacterium to efficiently penetrate tissue and to escape host immune responses.
It is shown that at night, the horizontally large scale SEF can efficiently penetrate into the ionosphere and produce noticeable changes in the horizontal distribution of the F region electron density.
This was the case for glyphosate (G) [17], the declared active chemical constituent of R. It is important to note thatG is only able to efficiently penetrate target plant organisms with the help ofadjuvants present in the various commercially used R formulations [18].
Both kinds of Dds very efficiently penetrate cells in culture [2], [4].
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In further experiments examining the invasiveness of tumor cells, we found that parental and control vector-transfected tumor cells efficiently penetrated the Matrigel-coated membrane, whereas the penetration rate of EBP1-transfected tumor cells was significantly reduced.
A key advantage is that NIR light efficiently penetrates tissue barriers associated with potential biomedical applications.
The vector efficiently penetrates the plasma membrane, is liberated in the cytoplasm and has a propensity to concentrate around the nucleus; up to 300000 particles can be observed in one cell in vitro.
We propose attaching BLM to a vector that carries out all these functions, namely efficiently penetrates the plasma membrane, is quickly liberated in the cytoplasm and has a propensity to concentrate around the nucleus [2].
Our results show that in humans, P. falciparum efficiently penetrates the feces at levels detectable by PCR.
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