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Joe Fiveash, the senior vice president for business and product development at Weather Channel Interactive Inc., which operates the site Weather.com, said that while the site had no shortage of large national advertisers, it did not have the sales force or the technology to efficiently insert ads of smaller advertisers in niches left open by the large advertisers.
For more than a decade researchers have been trying to find a way to efficiently insert corrective DNA into cells.
Importantly, these Bax mutants with the 6A7 epitope conformational change function as active forms of Bax that more efficiently insert into mitochondrial membranes leading to Cyt c release and apoptosis (Figs 1 and 4).
Our results strongly point towards an intrinsic ability of ACT to, directly and efficiently, insert into raft domains triggering there a range of different effects, without a strict requirement for receptors.
Altogether our results suggest that adenylate cyclase toxin, and maybe other homologous pathogenic toxins from the RTX (Repeats in Toxin) family to which ACT belongs, may be endowed with an intrinsic capacity to, directly and efficiently, insert into raft-like domains, promoting there its multiple activities.
Lentiviral vectors (LV) efficiently insert genetic cargo in both dividing and non-dividing cells and have attracted, therefore, major attention as a gene transfer tool.
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Specifically, the watermark data is efficiently inserted in host audio by taking advantage of both invariant EMs and quantization index modulation (QIM).
Perhaps most strikingly, a Cytb5OPG dimer modified with mPEG-5000 wastillll capable of being efficiently inserted into the ER membrane.
A transgene of ∼20 kb in size was efficiently inserted into the loxP site in the modified tet-O HAC by Cre-mediated recombination in CHO cells.
This strategy enables any DNA fragment containing the phage attL recombination sites to be efficiently inserted into the attR sites of the allele replacement vector using phage lambda clonase.
When pPrl alone was expressed, mainly prolactin of approx. 22 kDa was immunoprecipitated and only a small amount of pPrl accumulated, indicating that pPrl is efficiently inserted into ER membranes where its signal sequence is cleaved off.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com