In Study 1, we habituated infants to a rational agent, whose goal-directed actions were constrained by tall barriers, and then measured how long infants attended when the same agent navigated over a novel, low barrier efficiently or inefficiently.
This proves that PZA-LPPs dissolve fast upon deposition and that PZA crosses efficiently the lung barrier to reach the systemic circulation.
These old drugs have well-characterized pharmacological and safety profiles, low toxicity, and some cross the blood-brain barrier efficiently when a suitable route of administration is used.
The P2 receptor antagonist PPADS is thought not to pass the intact blood brain barrier efficiently because of its polar structure.
Objects larger than ≈30 kDa can efficiently cross this barrier only when bound to nuclear transport receptors (NTRs) that confer translocation-promoting properties.
Indeed, what the barrier efficiently retains in the mother cell is neither NPCs alone nor the unbound circles but rather the circle-bound NPCs.
Although cyclodextrin does not cross the blood-brain barrier efficiently, small amounts of cyclodextrin can enter the brain from the peripheral circulation.
This treatment is subcurative and although it clears the trypanosomes from the blood stream parasites within the CNS are protected from the drug since it cannot cross the blood brain barrier efficiently (Jennings et al., 1979; Sternberg et al., 2005).
To date, no cost-effective process for converting biomass to liquid fuels has been adopted for commercial-scale biofuel production, as we still do not know how to efficiently overcome the barrier of biomass recalcitrance.
This compound inhibits HDAC6 with an IC50 of 2 n m, and is 50- to 125-fold selective versus Class I HDACs (Fig. 4B), and crosses the blood brain barrier efficiently (Fig. 4C and D).
