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Once the vaccine reaches the MALT underlying the mucosa epithelium, efficient uptake, processing and presentation of antigens are demanded for APCs including macrophages, dendritic cells (DCs) and B cells.
However, it is currently unknown whether antigen adsorption to the nanoparticle or nanoparticle interactions with antigen presenting cells induces more efficient uptake, processing, and presentation of soluble antigen.
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RAB7 knockdown did not influence heparanase uptake, processing and activity.
mDCs are efficient in uptake, processing, and presentation of foreign antigens while pDCs are less effective in these processes.
The hybrid molecules showed a more efficient uptake and processing by dendritic cells resulting in a modified T cell response.
Efficient uptake of DNA is important for oligo-mediated recombination.
An efficient uptake of GRN163L without any need of transfection reagent was also observed for MM1S cells (not shown).
Gal-3 caused disruption of C. neoformans EVs, as well as an efficient uptake of EV contents by macrophages.
We used the hyper-permeable E. coli strain AS19 to obtain efficient uptake of the different molecules.
Cellular uptake and laser confocal microscopic studies reveal the efficient uptake of RuBP by M. tetragenus cells.
As Mfa-1 is required for efficient uptake of P. gingivalis by DCs, and is upregulated in the complete consortium, we hypothesized that consortium growth would increase uptake of P. gingivalis by MoDCs.
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