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Interestingly, adhesion of U937 to coated anti-α5 antibody clone JBS5 induced a strong adhesion without cell spreading by contrast with fibronectin and clone P1D6 (not shown and [25]) but was not efficient to trigger GSK3β dephosphorylation (Fig. 2C).
Comparison of phenotypes induced by MS1096, which allows specific expression of either Ey or Ey(2a) in the wing disc [44], revealed that Ey(2a) was less efficient to trigger ectopic eye structures in the adult wings than Ey (Fig. 4B, compare panels a and b).
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Ratté et al. also demonstrate that simultaneously increasing the sodium conductance and decreasing the potassium conductance is the most efficient way to trigger the hyperexcitability associated with neuropathic pain, whilst the opposite conductance changes are the most efficient way of relieving it.
Sulfur deprivation, which is considered as an efficient way to trigger long-term hydrogen photoproduction in unicellular green algae has two major effects: a decrease in PSII which allows anaerobiosis to be reached and carbohydrate (starch) storage.
It appears that apoptosis is a more efficient way to trigger cell death, as inhibition of autophagy and senescence by treatment with 3-MA and bafilomycin A1 enhanced cell death [ 68].
The fact that only professional phagocytes were able to internalize heat-inactivated EAs at levels comparable to control parasites suggests that intact surface molecules are necessary to promote efficient uptake and to trigger efficiently the signalling cascade that leads to internalization.
Unlike Ey, Ey(2a) has an impaired ability to trigger efficient ey target gene expression and to bind efficiently to DNA cognate sequences.
Efficient HIV vaccines have to trigger cell-mediated immunity directed against various viral antigens.
Our data also indicate that the endogenous ROS generated during I/R is insufficient to trigger efficient cardioprotection.
Accordingly, for most agonist ligands tested, faithful MHCI/CD8 interactions were required to trigger efficient IL-2 release.
This raised the interesting prospect that low abundance pervasive transcription would be sufficient to trigger efficient RNAi responses from sequences that undergo copy number amplification.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com