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Efficient screening of ligands interacting with G-protein-coupled receptors is central for modern drug development.
Fractional factorial designs, which allow efficient screening of many variables, are particularly important for industrial laboratories.
Well-designed assays, which may use specially prepared substrates, enable efficient screening of these mutant libraries.
Thus, DT40-SWΔC cells may be useful for constructing Ab libraries for efficient screening of mAbs in vitro.
In this regard, development of diagnostic markers becomes a prerequisite for efficient screening of known alleles of R genes in diverse germplasm.
The Dynamic Foam Analyzer enabled a quick and efficient screening of foaming agents by generating bulk foam and recording foam generation and its decay.
A novel PA Medium (PAM) for efficient screening of phosphate-accumulating organisms (PAOs) was developed taking Serratia marcescens NBRI1213 as model organism.
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This simple assay allows for a quick and efficient screen of hundreds of drugs to identify those affecting chromosome mis-segregation.
The highest rate of HAC mis-segregation was observed for the microtubule-stabilizing drugs, taxol and peloruside A. Thus, this new and simple assay allows for a quick and efficient screen of hundreds of drugs to identify those affecting chromosome mis-segregation.
In the performance analysis of the experimental approach, we found that, even with a low number of radioligand concentrations, an appropriate estimation of the dedicated K d was possible, making it suitable for cost-efficient screening of potential drug candidates.
Application of this technology will allow cost-efficient screening of genes known or suspected to harbor clinically relevant pathogenic mutations.
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