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The remarkable potency and selectivity of conjugate 1 can be attributed to highly FR-specific receptor-mediated endocytosis as well as efficient release of the unmodified cytotoxic warhead using a mechanism-based self-immolative linker.
In this work, we show that the efficient release of the prebound peptide during a DM-mediated exchange reaction requires the presence of an exchange peptide.
On the other hand, it ensures efficient release of the generated NO.
Once Stx2 is produced, efficient release of the toxin requires lysis of the bacteria.
First, it seems to be required for the efficient release of the mRNA from the anterior.
The highly specific sumoase facilitates efficient release of the antimicrobial peptide [ 12].
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Consistent with the Northern analysis, we detected high levels of exon 3 containing WT RNA in the nucleoplasm, indicating efficient release of these RNAs.
Whether SIVsmmPBj capsid components are required for efficient release of Vpx from the particles to the cytoplasm, for a certain activation of Vpx, or for nuclear localization of the PIC, remains still elusive.
In an attempt to improve the targeting and the efficient release of therapeutic compounds at the intra-cellular level of target cells, we have developed a novel magnetic field-controlled erythrocyte-based drug delivery system.
A carboxy-terminal 3xFLAG-tag was included for western blot detection and a precision protease (PSP) cleavage site was introduced between the repeat and reporter sequences to allow for efficient release of NLuc from the DPR.
Based on these results, this approach provides a new means for controlled and efficient release of RF using the PEA-NPs delivery system and is promising for the treatment of TB.
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CEO of Professional Science Editing for Scientists @ prosciediting.com