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Thus the presence of a guanine tract per se impairs the enzyme's functionality, possibly due to the tract's bulky nature and preventing efficient progression through the active site.
We subsequently performed a comparative analysis of phenotypes in these mutant strains and found that groups of LSU r-proteins are required for efficient progression of different steps of LSU maturation.
Detailed steady state and metabolic pulse labelling analyses of rRNA precursors in these mutant strains showed that LSU r-proteins can be grouped according to their requirement for efficient progression of different steps of large ribosomal subunit maturation.
Several factors contribute to this efficient progression.
One possible explanation is that CAF-1 is needed for efficient progression through the endocycle in trichomes.
We show that decorin overexpression in the MB49/MB49-I MB49/MB49-Iquired for efficient progression, by promodelg angisgenesis and tumourequirednvasiveness.
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How caspase cleavage of these proteins is coupled to efficient apoptotic progression remains uncertain.
We hypothesized that better uterine preparedness for labor as evidenced by more efficient labor progression would be associated with a more anaerobic post-delivery serum LDH isoenzyme profile.
Collectively, these studies propose a mechanism where Aurora A proximity to Plk1 facilitates efficient mitotic progression, as both kinases are constrained by Gravin.
Therefore, our results define a novel function for Hog1 at the stress loci that is the targeting of the RSC complex to a specific set of genes to mediate chromatin remodelling for efficient polymerase progression and proper gene expression and maximal cell survival upon stress.
Wnt3a is present at critical stages of human liver development and it elicits a rapid and efficient cellular progression of iPS cells to hepatic endoderm [ 27]. bFGF is secreted by the mesoderm and it is the first factor that commits the foregut endoderm to form liver primordium [ 28].
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