Thus, the fact that jugular blood BPA concentrations were transiently higher after sublingual administration than were those obtained after iv administration of the same dose suggests a rapid and efficient passage of BPA by the transmucosal oral route.
Perhaps an incubation time longer than 19 months is necessary for a detectable accumulation of lymphoid PrPCWD, or a larger dose of inoculum by the oral route is necessary for efficient passage of prions across the alimentary mucosa.
Our results indicate that the architecture of the two subdomains, most notably the strict conservation of key residues at the interface and within the 8 barrel, has been optimized to allow the efficient passage of ammonia, and not water, between the two remote active sites.
The volume of traffic on the road, West Lake Drive, was certainly not much of an issue back in the 1940's, but there was a clear public policy that balanced the protection of New York City's water supply with the efficient passage of civilian as well as emergency, police and military vehicles.
Even though the BBTB is considered 'leaky' in the core part of glioblastomas, in large parts of glioblastomas and, even more so, in lower grade diffuse gliomas the BBTB more closely resembles the intact blood brain barrier (BBB) and prevents efficient passage of cancer therapeutics, including small molecules and antibodies.
The significance of the varied interactions between the thalamus and cortex emerged from functional studies that sorted pathways into 'drivers', which ensure efficient passage of signals, and 'modulators', which evoke small and graded physiological responses on postsynaptic neurons [14] [17].
The "pedway" was an ambitious postwar plan to whisk pedestrians up from the car-choked streets of London and give them a utopia of streamlined paths and bridges, providing safe and efficient passage between the financial hubs of the Square Mile.
A difficult question is the efficient passage from analysis to synthesis.
Recently, mutant viruses capable of more efficient non-contact transmission arising from the passage of the H5N1 virus in ferrets and reverse genetics were found by two groups of scientists.
The neutralophilic bacterium has developed efficient mechanisms to cope with both the high acidity encountered during the passage of the stomach lumen in the initial phase of colonization and moderately acidic conditions expected to prevail in the mucous layer.
