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For efficient infection, we dissociated E13.5 rat pancreatic cells, infected them with adenoviruses and next reassociated the cells before culture.
Due to an efficient infection control, none of the medical personnel was infected with tuberculosis.
These reassortant viruses could preferentially recognize human-type receptors and resulted in efficient infection in ferrets, although they did not cause mortality in infected animals.
Furthermore, our data show a correlation between cell surface sialic acid availability and the efficiency of infection, suggesting that receptor availability may be a major determinant for efficient infection in respiratory epithelium.
Figure 5: G28A Jc1 requires fewer miR-122 molecules for efficient infection than WT.
Lopaticki, S. et al. Protein O-fucosylation in Plasmodium falciparum ensures efficient infection of mosquito and vertebrate hosts.
This could mean that there are significant differences in receptor recognition and affinity leading to more efficient infection by the H7N9 virus.
Zhou, F. C. et al. Efficient infection by a recombinant Kaposi's sarcoma-associated herpesvirus cloned in a bacterial artificial chromosome: application for genetic analysis.
One important challenge to reach the full therapeutic potential of oncolytic adenoviruses is accomplishing efficient infection of cancer cells and avoiding uptake by normal tissue through tropism modification.
We conclude that these metabolic traits are essential for sustainment of cell vitality and thus, a more efficient infection response.
The engineered liver tissues exhibit key features of advanced differentiation, such as human-specific cytochrome P450-mediated drug metabolism and the ability to support efficient infection with patient-derived inoculums of hepatitis C virus.
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