Thus, interference with peptide loading and trafficking of MHC I proteins to the cell surface is an efficient immune evasion strategy that evolved in CMVs.
Against a system effectively recognizing non-self molecules and mounting system-wide defense reactions in a circulatory system, a "stealth mode" is likely an efficient way of evasion.
Epidemiological evidence would suggest that herpesvirus antibody evasion is efficient enough even to avoid much selection of viral antigenic variants [4].
We therefore engineered MV-eGFP for IFN evasion and more efficient intratumoral spread by arming it with the P gene from wild-type IC-B strain MV, thus generating MV-eGFP-Pwt.
Thus, it seems clear that HIV-1 and its SIV precursors use Nef and Vpu to fine-tune NF-κB activity during the viral life cycle to achieve both efficient viral replication and immune evasion.
It is likely, that although the changes in our patient conferred immune evasion, another host may have highly efficient T-cells able to target the viral variants [61], [69], [70].
Successful delivery of therapeutic nucleic acids in clinical practice will depend on a variety of factors, from efficient production and purification of stocks to immune evasion and infection targeting.
This evasion proved amazingly effective.
This may be important for efficient virion release, or for other gp70 functions such as complement evasion [7].
Studies that define mechanisms of Leishmania pathogenesis, host immune evasion and exploitation have been particularly useful in designing efficient therapeutic strategies.
