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Studies of human intelligence provide strong evidence for the neural efficiency hypothesis, which suggests more efficient brain functioning (i.e., less or more focused activation) in more intelligent individuals.
We demonstrated that upon systemic AAV2/8 vectors-mediated liver targeting in MPS-IIIA mice, the chimeric sulphamidase was highly and sustainably secreted from liver and was able to efficiently cross the BBB resulting in efficient brain delivery.
Sleep deprivation is leading to less efficient learning, higher emotionality, increased anxiety, and a less efficient brain.
It might someday drive highly efficient brain implants that could help paralyzed patients move their arms and legs again.
Finally, the biodistribution study of CS-NLC-DiR demonstrated an efficient brain delivery of the particles after intranasal administration.
Effective, efficient brain healthcare must be seen not as a luxury for the few, but as a necessity for the many.
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These results provide an in-depth insight to create energy efficient brain-inspired neuromorphic devices in the future.
The proposed approach, by the use of efficient brain-like encoding mechanism, opens up new possibilities in information compression, communication and pattern recognition and thus is applicable to a range of new applications.
"What seems to happen in aging is that older people seem to have less efficient brains".
"My interpretation is that people who are more cognitively active have more efficient brains," Dr. Jagust said.
For an efficient brain-targeting therapy, the internalization and accumulation of carriers in brain cells are also important.
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