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Bootstrap resampling method might be another option to improve the efficiency of validation.
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Thus, translational medicine is not pretending to discover new goals and values but its essence resides more in emphasizing the need to enhance the efficiency of discovery validation recognizing the increasing obstacles.
Improving the efficiency of model validation and model update is essential for reducing the time and effort required to construct high-quality biological pathways.
To improve the efficiency of protein validation, Peptide Mascot Score >23 (peptide with a high likelihood of matching >95%) and significant differences (ratios <0.5 and >2) of protein expression were both used as selection criteria.
The efficiency of cross-validation and its difference from hold-out validation strategy lies in the fact that the partitioning is made not in a pre-determined but in a random way and the procedure is repeated multiple times so that each partition can be used as test set at least once.
A Monte-Carlo simulation is carried out to compare the efficiency of generalized cross validation and L-curve validation to choose the Tikhonov regularization parameter.
In the strategy sections immediately below, we further explain the principles of maximum efficiency of development and validation of predictive biomarker hypotheses against clinical benefit.
Additionally, the filter produces a small number of discriminative genes for improved phenotype prediction, which is advantageous for the domain user since a small number of candidate genes supports greater efficiency of in vitro validation.
The final classification was performed by multilayer perceptron (MLP) and decision tree (DT) classifiers, reaching an overall validation efficiency of 100%and99.5%5%, respectively.
The efficiency of those scores requires validation in SAH populations.
The efficiency of SNP discovery and validation may be further increased through targeting of the transcriptome (RNAseq; [ 6]) or restriction-site associated DNA tags (RAD; [ 7, 8]).
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