Sentence examples for efficiency of translation of from inspiring English sources

In some metazoan species (e.g. Drosophila and nematode), synonymous codon usage appears to evolve under selective pressure to optimize the efficiency of translation of highly expressed genes (the translational selection model) [ 69].

Another issue that is not generally considered is the effect that editing may have on the efficiency of translation of an edited mRNA, not just its translatability per se or the properties of the final protein product.

The central concept of translational regulation is that cellular gene expression is governed by the efficiency of translation of a given mRNA in the absence of a corresponding change in steady-state mRNA levels [ 16].

Stress related phosphorylation of eIF2α decreases the general level of translation, but the efficiency of translation of several cellular mRNAs increases during the stress [62] [64].

Studies of the functional role of CGG repeats in the 5'UTR of the human FMR1 gene demonstrated that these repeats may exert both positive and negative effects on the efficiency of translation of FMR1 mRNA, depending on repeat length.

While the consequence of this upregulation might be expected to be an increase in translation rates of all mRNAs, in actuality the increase in these eIF4E levels results in preferential increase in efficiency of translation of a select group of mRNAs encoding proteins likely to be involved in tumorigenesis and tumor progression [2], [3], [7].

The expression of collagen VI chains is highly regulated at different levels such as gene transcription, processing of encoding RNAs, efficiency of translation and post-translational modifications [22], and the impairment of the efficiency of each step may affect protein assembly and secretion.

The synonymous position affects either the efficiency of translation (and hence the cost of expression) or translational accuracy (and hence the mean specific activity of the protein produced).

The efficiency of translation initiation depends on the arrangement of nucleotides surrounding the translational start codon, so the AUG context is thought to be an important regulatory factor (reviewed in [ 36]).

The dependence of efficiency of translation initiation on mRNA sequence parameters was investigated in an Escherichia coli in vitro expression system.

Differences in expression appeared was mainly related to the efficiency of translation initiation and the stability of mRNA secondary structure, because the intracellular mRNA levels analyzed by real-time RT-PCR were quite similar.