Sentence examples for efficiency of trail from inspiring English sources

Finally, we present data indicating that "normalization" of the tumor microenvironment by vitamin D3, a potent chemopreventive agent, restores the sensitivity of colon cancer cells to TRAIL, suggesting that the therapeutic efficiency of TRAIL may be greatly improved by agents that inhibit the crosstalk between tumor cells and the tumor microenvironment.

Many recent studies have focused on boosting the efficiency of TRAIL-induced apoptosis against tumor cells by combined treatment with additional substances [ 7, 17- 19] to overcome their resistances.

To further optimize the treatment efficiency of TRAIL-based cancer drugs, targeting concepts have been evaluated which serve two main purposes: 1) to accumulate the drugs at the tumor site and thereby limiting sequestration by non-transformed host cells (reduced side-effects) and 2) to immobilize TRAIL to the cancer cell membrane which converts a soluble drug into a membrane-bound analog.

A number of recent clinical trials in phases Ib and II demonstrate safety and efficiency of using TRAIL-related apoptogens (the recombinant ligand or agonist monoclonal antibodies) that trigger TRAIL receptors in combinatory treatment of advanced NSCLCs with conventional therapeutic drugs paclitaxel, carboplatin, and bevacizumab.

Placing one HAWT in another's draft drastically reduces the efficiency of the trailing windmill.

The quality of the results obtained when solving three sets of benchmark problems is superior to that of the best solutions found in literature and shows the efficiency of the specialized trail.

For analysis of Ad-TRAIL transduction efficiency of CD34+ cells, cells were incubated with phycoerythrin (PE -conjugated anti-TRAIL antibody [clone Rik-2; Becton–Dickinson (B-D), San Jose, CA, USA] and alloPE -conjugatedPC)-conjugated CD34 antibody (B-D).

On all cancer cell lines tested, including primarily TRAIL-resistant A549 cells, already low concentrations of TRAIL (1 10 ng/ml) in the presence of SNS-032 (300 nM) were sufficient to reach maximum efficiency in killing these cells.

Indeed, Killer-TRAIL, a commercially available active form of TRAIL exerted only a weak IL-8-inducing effect in HeLa-CD40 cells, although it triggered apoptosis with high efficiency under CHX-sensitized conditions.

Those experiments have shown very little impact of trail parameter on the particle rejection efficiency.

Future polychemotherapy protocols might position TRAIL in close relation to cell cycle in order to gain highest antitumor efficiency by TRAIL, based on the molecular understanding of drug drug interactions.