Sentence examples for efficiency of gene delivery from inspiring English sources
However, during intracellular delivery of these carriers, multiple barriers have to be overcome or the efficiency of gene delivery will be impeded.
To demonstrate cellular selectivity toward hepatoma cells and compare the efficiency of gene delivery of a novel nonviral vector of iopamidol, protamine, and ethiodized oil reagents (VIPER).
However, it has, thus far, proven difficult to develop delivery vehicles that increase the efficiency of gene delivery to hMSCs, due to several problematic issues.
Issues that hampered clinical successes include the specificity and efficiency of gene delivery; the immune response to viral vectors and targeted cells; standardized and affordable production of vectors; and safety for patients and environment.
In this study, we fabricated multiple QD bundled nanoparticles (NPs) to investigate the effect of QD size and poly ethylenimine) (PEI) coating on the efficiency of gene delivery into human mesenchymal stem cells (hMSCs).
In the longer term, it should be possible to improve the efficiency of gene delivery by learning from the attributes which viruses have evolved; attributes that enable translocation of viral components across biological membranes.
However, lipofection using some of the last generation cationinc lipids, LipofectAMINE-2000 or LipofectAMINE-Plus (Invitrogen), yielded higher efficiencies of gene delivery, particularly with PC-12 cells (M. González-García and R.P. Ballestero, unpublished observations).
A previous report on HGD adopted naked plasmid DNA for the transfection of hepatocytes, but achieved a relatively high degree of gene delivery efficiency [ 7].
The main task of a viral vector is to deliver its nucleic acid cargo with high efficiency, typically as a means of gene delivery with therapeutic purpose.
Gene therapy and DNA vaccination trials are limited by the lack of gene delivery vectors that combine efficiency and safety.
Two main challenges in design of gene delivery vectors is decreasing cytotoxicity while improving the transfection efficiency.
