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14 Clinical efficacy was calculated in an modified intention-to-treat (mITT) and per-protocol analysis.
At each faecal sampling time, arithmetic mean EPG were calculated as recommended by the WAAVP guidelines for evaluating the efficacy of anthelmintics in ruminants and, for each treatment group, percent efficacy was calculated in terms of Faecal Egg Count Reduction (FECR) at the different days [ 19, 22].
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Vaccine efficacy was calculated as 1- prevalence in the vaccinated/prevalence in the unvaccinated).
Vaccine efficacy was calculated from the exact conditional procedure and is included in the Kaplan-Meier plots as a reference.
The prevented fraction to determine vaccine efficacy was calculated as follows: 1 − [ incidence of persistent antigenemia in vaccinates)/(incidence of persistent antigenemia in controls)].
For each method, the therapeutic efficacy was calculated as the ratio of number of exams indicating changes in management to the total number of exams.
Efficacy was calculated based on the reduction of the geometric mean worm counts in the treated groups versus the placebo-treated control groups.
Protective efficacy was calculated as (1−IRR)×1−IRR
Efficacy was calculated for matGC and 4wpiGC.
* The efficacy was calculated using geometric means.
Efficacy was calculated as previously described [ 18].
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