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Primary equivalence of efficacy was assessed using the BPI assessment of 'worst pain in the past 24 hours' on an 11-point scale ranging from 0 (no pain) to 10 (worst pain imaginable).
Efficacy was assessed using change from baseline to endpoint in total scores of the following assessment tools: MADRS: A clinician-administered interview regarding symptoms of depression in the previous week, and consisting of 10 items, each scored from 0 to 6 in increasing order of severity.
The antinociceptive efficacy was assessed using thermal and mechanical models of nociception.
Efficacy was assessed using change from baseline in HAM-A total scores after 8 weeks of treatment compared with placebo, using mixed-model repeated measures (MMRM) analyses.
Main Outcome Measures: Efficacy was assessed using Brief Pain Inventory (BPI), McGill Pain Questionnaire (MPQ), Neuropathic Pain Scale (NPS), Sleep Quality Scale (SQS), and Beck Depression Inventory (BDI).
When renal denervation efficacy was assessed, using measurements of the spillover of norepinephrine from the renal sympathetic nerves to plasma, the only test validated to this point, denervation was found to be incomplete and nonuniform between patients.
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Efficacy is assessed using observer and self-report efficacy measures of depressive symptomatology.
Participants' confidence to exercise in the face of obstacles (barrier efficacy) is assessed using the Barriers Efficacy Scale [ 50].
Cytokines levels potentially related to cetuximab efficacy were assessed using multiplex-bead assays and enzyme-linked immunosorbent assay at baseline, at week 8 and at week 17.
Exercise self-efficacy was assessed using the CSAPPA Scale.
Student self-efficacy was assessed using the Evidence-Based Practice Question (EBPQ) [ 21].
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