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Considering the integral role of PK in drug efficacy, use of pediatric PBPK models can serve to integrate multiple levels of information (i.e., in vitro, preclinical, clinical, etc).
Therefore, although rhBMP-2 appears to be a promising alternative to autogenous bone grafts for alveolar ridge/maxillary sinus augmentation, dose and carrier optimization are being profoundly studied to expand its efficacy, use, and clinical application [ 74].
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Recent clinical studies have demonstrated incompletely effective anti-tumor immunotherapy efficacy using dendritic cells (DC) vaccines.
This is followed by a more rigorous qualitative evaluation of GIGAME's educational efficacy using the RETAIN framework.
Hemodynamics in cerebral aneurysms are currently investigated toward clinical efficacy using nonstandardized computational simulation techniques.
Deoxyribozymes (Dzs) were tested for cleavage efficacy using in vitro transcribed Cx31.1 mRNA.
We followed up the efficacy using MRI evaluation in addition to macroscopic and histological observations.
The synthesized compounds were tested for their glucosidase inhibitory efficacy using acarbose as a standard inhibitor (IC50 = 38.2 ± 0.12 µM).
We determined that the critical parameter for in vivo efficacy using aggressive mouse tumor models was the choice of adjuvant.
Lamivudine (3TC) is an antiviral drug with a widely demonstrated clinical efficacy used to treat Acquired Immunodeficiency Syndrome (AIDS) in humans.
Noticeably, several Aβ ligands [44 46] and disease-modifying therapeutics have been investigated for their efficacy using APP+/−/PS1+/− transgenic models [47, 48].
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