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Because of the variability of the estimates reported in literature and potential variability in treatment efficacy, we conducted sensitivity analyses on the majority of model inputs – treatment efficacy, transition rates, health state costs, and the quality of life associated with the health states.
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Therefore, research on the efficacy of transition programmes in other countries is warranted.
When patients discontinue the first AAP for any cause (adverse event or lack of efficacy), they transition to a "composite" AAP.
The composite AAP therapy was incorporated into the model to account for treatment switching within a single state, as patients remain on the composite therapy until they fail due to lack of efficacy and transition to clozapine.
36 We propose to use an RCT to provide high-quality evidence regarding the efficacy of transitioning from conventional shoes to minimalist shoes.
We hope that researchers will use, refine and develop the model and framework for use in future studies to advance understanding and develop and evaluate new interventions to promote self-care and self-efficacy at transition.
The greatest efficacy of polymorphic transition of cellulose was noted in the highest concentration of NaOH solution.
The efficacy of this transition control framework is demonstrated on two nonlinear single-input single-output reactors in the face of modeling errors, parameter uncertainties and disturbances.
The strong liaison between the clinical and laboratory teams, and the structured framework for technology transfer and health policy decisions within Canada will increase the speed and efficacy of this transition, and the value of this translational research.
Together these findings raise serious questions about the efficacy of current transition procedures.
The efficacy of these transition programmes has been evaluated to some extent in the last decade.
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CEO of Professional Science Editing for Scientists @ prosciediting.com