The overall aim of this final model could be, when correlated to PD or efficacy data, to serve as a tool to guide selection of optimal dose regimens for matuzumab, a highly promising 'targeted' cancer therapy.
Indeed, MHC class I restricted CD8+ T cells that specifically lyse tumor cells in vitro are frequently measured to document vaccine efficacy and to serve as a surrogate end point in clinical tumor vaccine trials [ 12, 47, 48].
As noted by Bennett, chemotherapy is associated with a reduction in the efficacy of gut mucosa to serve as a barrier against microbial invasion leading to an increased risk for infection [ 10].
Proteomic, genomic, in vivo, and human clinical studies are needed to determine the efficacy of the fruit extract to serve as natural cytotoxic agent in cancer patient.
The methods he and his MSKCC colleagues developed continue to serve as models for evaluating the efficacy of new analgesics and for measuring patients' differing sensitivity and tolerance to these drugs.
Taken together, the use of descriptive NES values offers the potential to serve as a predictor of anti-primary and anti-metastatic efficacy, as well as to serve as a tool to compare treatments and predict drug combination strategies to improve overall outcome.
The statistical boundary, requiring p < 0.0039 at the interim analysis to halt due to efficacy, will serve as a guide.
Best of all, it creates a living laboratory to assess the efficacy of regulations when it comes to serving consumers' needs and solving banking problems.
Failing to address women's sense of childbirth self-efficacy may serve to set them up for a distressing and dissatisfying birth experience.
The plant toxin saporin linked either directly or via the adapter to epidermal growth factor (EGF) served to evaluate efficacy to inhibit tumor growth and reduce side effects in vivo.
The second aspect is more challenging and important; can the biomarker predict the clinical endpoint of efficacy and serve as a surrogate endpoint?
