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To evaluate the cost-effectiveness of intracameral cefuroxime for postoperative endophthalmitis prophylaxis, and to determine the efficacy threshold necessary for alternative antibiotics to attain cost-effective equivalence with intracameral cefuroxime.
Thereafter, current was lowered until contralateral arm rigidity returned to baseline severity (efficacy threshold).
TW (in mA) was calculated for each tested PW by subtracting the efficacy threshold from the side effect threshold.
Unexpectedly, nearly 60%% of patients had (Z -endoxifen plasma level below the 5.97 ng/ml efficacy threshold.
Tumor cell resistance and dose-limiting toxicities frequently result in administration of molecularly targeted agents below the efficacy threshold in patients.
Indeed, our PK results and proposed efficacy threshold are different from those observed in a cohort that included a majority of patients with lupus nephritis [ 12].
Similar(47)
Kern, K. A. Trial design and efficacy thresholds for granting breakthrough therapy designation in oncology.
Different efficacy thresholds might be used in environments where MIC90 values of relevant pathogens differ from 2 mg/L.
We thought that pooling systemic vasculitis and SLE patients would prevent a clear general definition of 'flare' and thereby introduce bias into the determination of efficacy thresholds.
For a reduced-efficacy threshold of 90%, most combinations resulted in a reliable detection of reduced and normal efficacy.
For the reduced-efficacy threshold of 95% however, unreliable FECRT results were found when sample sizes <15 were combined with highly aggregated FEC (k = 0.25) and detection limits ≥5 EPG or when combined with detection limits ≥15 EPG.
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