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These advances have transferred emphasis away from the identification of potent kinase inhibitors and more towards issues of target selectivity, cellular efficacy, therapeutic effectiveness and tolerability.
The opportunity to assess drug exposures, toxicity and efficacy (therapeutic index) in a single large animal model is highly informative.
Taken together, this model suggests that there is a need for development of high efficacy therapeutic approaches towards the specific inhibition of HDV replication.
The results suggest that there is a need for development of high efficacy therapeutic approaches towards the specific inhibition of HDV replication.
METRIC aims to compare the diagnostic efficacy, therapeutic impact and cost effectiveness of MRE and USS in newly diagnosed and relapsing CD.
Available therapies, including radiation, endocrine, and conventional chemotherapy, are often limited by high toxicity, lower efficacy, therapeutic resistance, and therapy-related morbidity.
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Efficacy of therapeutic interventions, e.g. within the scope of a drug screening or therapeutic exon skipping, can be monitored.
It can also be used to assess the efficacy of therapeutic measures and any related complications.
Clearance has a critical impact on the efficacy of therapeutic antibodies.
There is a need for diagnostic accuracy studies on 2D lateral cephalometric radiograph where standardised methodological criteria for diagnostic thinking efficacy and therapeutic efficacy are incorporated.
It could also include animal model efficacy and therapeutic index studies.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com