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These challenges include the need to detect and quantify various phenomena when screening for allosteric ligands, such as saturability of effect, probe dependence, differential effects on orthosteric ligand affinity vs. efficacy, system-dependent allosteric agonism, stimulus-bias (functional selectivity), and the potential existence of bitopic (hybrid orthosteric/allosteric) ligands.
Independent variables included in this study are e-learning system quality, information quality, computer self-efficacy, system-use, self-regulated learning behavior and user satisfaction as prospective determinants of online learning results.
We have demonstrated its efficacy for systems exactly meeting its tree-like assumptions, for systems that only slightly deviate from tree-like assumptions, and for systems that deviate substantially from tree-like assumptions.
The efficacy of systems is still debated [ 2, 3].
The efficacy of the system is illustrated using a reported system implementation.
Other states have expressed confidence in the efficacy of the system.
"From a military perspective, the Israelis have every interest in overstating the efficacy of the system in order to deter missile launches," he said.
Encouraging experimental results confirm the efficacy of our system.
Different hand sizes have a big impact on the efficacy of the system, and as such, my own demo was a bit frustrating.
Our research findings demonstrate the efficacy of the system using responses to both ACORNS and ACORNS-like assessment items.
The efficacy of our system is demonstrated using both simulations and real-world executions in the experimental section.
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