Lack of patient compliance, due to undesirable side effects and efficacy restricted to positive symptoms, highlights the need to develop novel therapeutics.
The following exclusion criteria were defined: trials with no comparator (ie, warfarin), namely observational studies including only patients treated with dabigatran; starting of dabigatran treatment only after catheter ablation; and evaluation of efficacy restricted to laboratory or imaging end points.
Abrogation of this axis has demonstrated therapeutic efficacy in restricting tumor-mediated osteolysis in vitro as well as in animal models of metastasis [ 31, 34, 43- 45].
The main challenge therefore is how to influence the process of natural selection, in other words how to minimize exposure of micro-organisms to antimicrobials without compromising their efficacy or restricting its use to those patients that need them.
Perhaps a less contentious use of nomogram estimates in this setting relates to patient selection: one might hope to improve patient homogeneity, or the possibility of discerning treatment efficacy, by restricting entry to patients at perceived higher risk of progression.
Conventional PDT efficacy is restricted by insufficient selectivity, low solubility of photosensitizers, and limited penetration depth of the 630-nm laser light, which reduces the PDT efficacy for tumors located in deeper tissues compared with those at the body surface.
The prospective analysis of in vivo efficacy was restricted to studies after 1994, when distinction of recrudescent from novel infections was made possible by the introduction of PCR parasite genotyping [20], thereby ensuring accurate assessment of recrudescence rates.
Using this collection, we showed that nutlin3a efficacy was restricted to TP53 wt HMCLs in a p53-dependent manner.
Hemodiafiltration (HDF) has shown its potential in better removal of small as well as large sized toxins, but its efficacy is restricted by inter-compartmental clearance.
Both cetuximab and panitumumab are active as single agents in chemorefractory metastatic disease as well as in combination with various chemotherapy regimens, but efficacy is restricted to patients with wild-type (wt) KRAS status (Chu, 2012).
