Failures of molecules in Phase III for poor efficacy raise questions about target identification and validation.
The robust efficacy raises intriguing questions about earlier PrEP studies.
The observation that sensitivity can increase after up to two months of low treatment efficacy, raises questions about the practice of automatically changing therapy after a poor initial response, and about the optimal number of cycles in some patients.
This lack of clinical efficacy raises a question: Could concurrent Ang1 inhibition actually be compromising the anti-metastatic efficacy of Ang2-specific inhibition by destabilizing systemic blood vessels to promote distant metastatic spread, despite the expected additive benefit in local tumor growth suppression (Cascone & Heymach, 2012)?
MCV efficacy after a single dose depends on the age of vaccination: 85 % of children seroconvert after receiving a shot when vaccination is done at the age of 9 11 months whereas after 1 year of age, vaccine efficacy raises to 95%% [ 7].
Recent LLIN assessments in Kenya and Benin, reported a faster-than-anticipated loss of physical (durability) and insecticidal integrity (bio-efficacy), raising concerns about the duration of LLIN effective life [ 15, 16].
Our finding that participation in CME and physician beliefs are both important factors in self-efficacy, raises the intriguing possibility that some of the benefits of participation in CME may be mediated through effects on attitudes and beliefs over-and-above simple knowledge acquisition.
It remains to be investigated whether this will lead to improved treatment efficacy without raising concern about toxicity.
This shows Abraham's efficacy in raising digital revenues, not least through the internet service All4, which has become a sustainable data company of its own accord.
Effective EPIs could significantly improve antibiotic efficacy by raising physiological levels of an antibiotic and act synergistically by reducing bacterial efflux [ 22].
65 In the evaluation interview, clinicians should promote self-efficacy by raising the hope that lifestyle changes can be attained.
