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The robust efficacy raises intriguing questions about earlier PrEP studies.
The observation that sensitivity can increase after up to two months of low treatment efficacy, raises questions about the practice of automatically changing therapy after a poor initial response, and about the optimal number of cycles in some patients.
MCV efficacy after a single dose depends on the age of vaccination: 85 % of children seroconvert after receiving a shot when vaccination is done at the age of 9 11 months whereas after 1 year of age, vaccine efficacy raises to 95%% [ 7].
This lack of clinical efficacy raises a question: Could concurrent Ang1 inhibition actually be compromising the anti-metastatic efficacy of Ang2-specific inhibition by destabilizing systemic blood vessels to promote distant metastatic spread, despite the expected additive benefit in local tumor growth suppression (Cascone & Heymach, 2012)?
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Failures of molecules in Phase III for poor efficacy raise questions about target identification and validation.
Our finding that participation in CME and physician beliefs are both important factors in self-efficacy, raises the intriguing possibility that some of the benefits of participation in CME may be mediated through effects on attitudes and beliefs over-and-above simple knowledge acquisition.
Recent LLIN assessments in Kenya and Benin, reported a faster-than-anticipated loss of physical (durability) and insecticidal integrity (bio-efficacy), raising concerns about the duration of LLIN effective life [ 15, 16].
As new learning methods improve in efficacy, it raises important questions: Will higher ed's diplomas and traditional classroom education be devalued?
Although a number of anti-VEGFR therapies have been conceived, inefficient drug administration still limits their therapeutic efficacy and raises concerns of potential side effects.
It remains to be investigated whether this will lead to improved treatment efficacy without raising concern about toxicity.
Combination therapy targeting renal filtration could increase therapy efficacy and raise tumour pHe.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com