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Efficacy of monotherapy seroquel in BipOLarDepressioN.
These findings were subsequently confirmed in the similarly designed EMBOLDEN (Efficacy of Monotherapy Seroquel in BipOLarDepressioN) I and II trials (McElroy et al. 2010; Young et al. 2010).
The results of this study show the efficacy of monotherapy for relapsed SCLC.
The results of the studies which demonstrated the efficacy of monotherapy for relapsed SCLC involved mainly Japanese patients.
Clinicians do not appear to have as much confidence in the efficacy of monotherapy with aripiprazole compared to risperidone, as evidenced by the smaller market share of aripiprazole relative to other first line antipsychotics.
While therapeutic efficacy of monotherapy with TZDs was relatively low, data obtained from meta-analysis of diabetes studies as well as in vitro data suggested that TZDs could be efficient in chemoprevention (Table 2).
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These results demonstrate the superior efficacy of tocilizumab monotherapy over methotrexate monotherapy regardless of previous methotrexate exposure.
The difference between direct and indirect evidence was higher when considering the incremental efficacy of ranibizumab monotherapy over laser monotherapy (2.5 letter difference between the indirect and the direct evidence), although this difference remained non-significant (p=0.61).
We investigated the safety, tolerability and efficacy of liraglutide monotherapy compared with glimepiride monotherapy over 2 years.
The present results suggest that the efficacy of metformin monotherapy or anti-glycolytic monotherapy can be synergistically enhanced when used together.
This unintended outcome limits the efficacy of MET-disrupting monotherapy; further proliferation may also be driven by aberrant mutational activation of the RAS MEK pathway.
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