The convenience of once daily dosing outweighs the potential for a lower efficacy as identified in a Cochrane review [ 39].
Objective To test the efficacy of lower doses of mifepristone and gemeprost for medical induction of early abortion.
Objective: To evaluate the efficacy of lower doses of conjugated equine estrogens (CEE) plus medroxyprogesterone acetate (MPA) for relieving vasomotor symptoms and vaginal atrophy.
We further investigated the protective efficacy of lower doses of WNIG and IVIG-IL.
Evidence is lacking on the safety and efficacy of lower doses of primaquine.
Although some evidence suggests that lower doses of misoprostol may have the same effect on the uterus compared with higher doses [ 17], no large randomized controlled trials have been conducted confirming the efficacy of lower doses for treating PPH.
The superiority of the 5,000-unit 5,000-unitIFN-α over the 30,000-unit dose is cofsistent with human and animal data supporting greater efficacy of lower doses of ingested interferon in autoimmune disease (15, 16, 22).
One such strategy for improving the risk/benefit profile of this agent has been to examine the efficacy of lower doses, which are anticipated to be associated with lower toxicity.
These findings, together with the reports of efficacy of lower doses of erlotinib in patients with known EGFR mutations suggest that, in the presence of rash, dose reductions to 'subtherapeutic' levels remain effective and may prevent unnecessary early treatment termination (Lind et al, 2009).
In this study, we examined the efficacy and safety of lower dose (1 mg/kg/day) of rosiglitazone, a thiazolidinedione, in combination with 5 mg/kg/day dose of LAF-237 (vildagliptin), a known DPP IV inhibitor, in aged db/db mice after 14 days of treatment and compared the combination with therapeutic dose (10 mg/kg) of rosiglitazone.
