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CA125 was the primary efficacy measurement for the remaining patients without measurable disease.
Changes in body weight, BMI and waist circumference between groups were compared in the 'efficacy population', composed by those with at least one efficacy measurement available after randomization.
These issues have implications for treatment decision making, efficacy measurement, and the design of research studies.
Political efficacy measurement contains two index, external efficacy factor and internal efficacy factor.
Patients that completed the study at 6-weeks from a total of 505 randomized subjects receiving at least one dose of study medication at doses of 20 60 or 80 120 mg/day, with at least one baseline measurement of the MADRS and one post-baseline efficacy measurement for the MADRS formed the analytical sample (defined as the completer population).
All efficacy analyses were performed on the intent-to-treat (ITT) population, defined as all randomized patients who had a baseline efficacy measurement, received ≥1 dose of study drug, and had ≥1 post-randomization efficacy measurement.
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The delay of events measure should not replace the established efficacy measurements.
Secondary outcome measures included the safety of E7080, its PK profile and efficacy measurements.
Exploratory efficacy measurements included WHO functional class and parent's and clinician's Global Clinical Impression scales.
We test this hypothesis using a luciferase reporter system and obtain additional evidence from a variety of large-scale data sets, including microRNA overexpression experiments and RT qPCR-based efficacy measurements for thousands of siRNAs.
Surfaces will likely be contaminated via an aerosol exposure and thus antimicrobial efficacy measurements should also be performed using biological aerosols.
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