Sentence examples for efficacy issues with from inspiring English sources
Safety and efficacy issues with current antiplatelet therapies, including investigational PAR1 antagonists, highlight the need for antiplatelet agents that may act via alternative mechanisms.
These relate particularly to mode of action, safety and efficacy issues; with respect to the latter, questions such as optimal dose regimen, direct comparison with other biological agents and indicators for retreatment require appropriate answers.
A wide array of polymeric- as well as lipid-based nanocarriers (NC) such as dendrimer, carbon nanotubes, and liposome have been explored but there are biodegradability, toxicity, and poor efficacy issues associated with them [ 3, 5, 6].
Failure to grapple with such efficacy issues is likely to lead to distortions (based on attrition, representativeness and perverse incentives) in the yielded data.
Attrition causes analytical and efficacy issues in weight loss trials.
Thus, ADA-based safety or efficacy issues are circumvented.
Trials that assessed this specific efficacy issue recruited patients with short-lasting, less severe disease showing high responses to both experimental and control treatments, thus explaining the lower relative and absolute efficacy estimates (Table 4).
Neutralizing antibodies against the botulinum toxin may lead to issues with efficacy, and ultimately treatment failure as described above.
As highlighted and discussed by the authors, the therapeutic outlook of a new class of low-molecular-weight non-peptide caspase inhibitors is promising for the development of future therapeutics, but issues with efficacy and toxicity need to be resolved.
In addition, YHC professionals' communication skills and self-efficacy in discussing weight issues with parents of overweight children appear insufficient.
