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The overall efficacy is marginal however.
Typically, the composition of such agents is largely based on institutional folklore and objective assessments of their efficacy is marginal.
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There have been only 5 randomised controlled trials of statins in patients with prior stroke or TIA (total n = 9224) and the estimate of efficacy in preventing recurrent stroke is marginal (10.8% statin vs 12.1% control; odds ratio [OR]: 0.88, 95% CI: 0.77 to 1.00) (Manktelow and Potter, 2009).
Twee is marginal.
But this relationship is marginal.
However, the difference is marginal.
Bicycle use is marginal.
"Food is marginal at best.
An alternate approach would be to assume independence between Y T and Y E, in which case the joint probability of toxicity and efficacy is simply the product of the marginal probabilities, (5) π (y T, y E | z ) = π T y T (1 − π T ) 1 − y T π E y E (1 − π E ) 1 − y E, which is of course what we get by setting ψ1=0.5 and ψ2=0 in the Braun and Gumbel copulas, respectively.
Efficacy is important.
Today, efficacy is the challenge.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com