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This reduction in lubricant additive efficacy is due to the fact that the additives were designed and optimized for ferrous surfaces.
Aside from environmental pressure and overuse, another cause for this rapid loss of efficacy is due to the fact that most available antibiotics are derived from a compound discovered in a microbe for an example, penicillin, Fig. 1.
We saw no effect of ibandronate on the breast cancer cells in 2-D or in pre-cultured 3-D models with existing tissue formation, supporting our contention that drug efficacy is due to the effects of HA binding.
It is not yet known whether this lack of efficacy is due to an insufficiently robust immune response, to failure of allele-specific antibodies to protect against the wide array of AMA1 variants, or because immune responses to AMA1 alone are simply unable to prevent clinical malaria.
A major limitation of cisplatin efficacy is due to intrinsic or acquired resistance by tumour cells.
This failure to examine their efficacy is due to a variety of reasons, which are outlined in the presentation.
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The high efficacy was due to the nano-sized particles enhancing adhesion and penetration of the Av pesticide on the surface of crops, which reduces loss of pesticide due to leakage during spraying.
Our subsequent pharmacodynamic studies demonstrated that in the schedule where docetaxel was administered first we saw enhanced cleaved caspase 3 signalling, suggesting that the enhanced efficacy was due to enhanced apoptotic signalling.
Further experiments confirmed that this increase in efficacy was due to a remarkable switch from the RNA to the DNA activation pathway, with increased formation of active FdUMP when 5-FU was modulated with d-Ino.
Neither KDM4A overexpression nor H3.3K36M expression affected cell cycle progression as assessed by BrdU incorporation, thus excluding the possibility that the reduction in RPA, RAD51 foci formation and HR efficacy was due to cell cycle effects.
From the clinical experience with purified recombinant IL-1Ra it became clear that most of the problems of variability of efficacy were due to difficulties in adequate timing and dosage of the drug [ 12].
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CEO of Professional Science Editing for Scientists @ prosciediting.com