Sentence examples for efficacy in the second from inspiring English sources

8 The authors hypothesized that axitinib's efficacy in the second- and third-line setting after prior TKIs might have been due to axitinib's high potency and high selectivity for VEGFR1, VEGFR2, and VEGFR3.

A subsequent study showed that a modified 5-FU schedule combined with 85 mg m−2 but with reductions of both oxaliplatin and 5-FU for haematologic toxicity once again reducing the oxaliplatin dose, was associated with marked reduction in efficacy in the second line setting – 12% in 37 patients but with a remarkable 72% response rate in 25 first-line patients (Cheeseman et al, 2002).

Improved teacher efficacy in the first treatment group persisted throughout the second school year.

Combination of trastuzumab and pertuzumab has also demonstrated clinical efficacy in the second-line setting (Cortes et al, 2012).

Finally, sorafenib and everolimus have also shown efficacy in the second-line setting (Escudier et al, 2007a; Motzer et al, 2008b).

Axitinib, a more recently developed TKI, has shown efficacy in the second-line setting in patients that progressed on first-line TKI therapy [ 16] and is now recommended for mRCC in this setting.

In conclusion: (I) OxFU (OxMdG) and OxCap (XELOX) have similar efficacy in the first-line treatment for aCRC.

Combinations of cetuximab and 5-FU/FA/oxaliplatin have also shown efficacy in the first-line treatment of mCRC.

Available data suggest that different platinum/third generation chemotherapy agent combinations have similar efficacy in the first line setting [ 3].

The pragmatism of the intervention changed with time, moving from efficacy in the first four hours to effectiveness in the second 24 hours.

For many years, panitumumab has remained an important agent in the treatment paradigm for KRAS-WT mCRC with demonstrated efficacy in the first-, second-line and chemorefractory settings.