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Different surrogate markers of tissue oxygenation have been used to explore the relationship between duration of RBC storage and their efficacy in restoring optimal tissue oxygenation.
Epigenetic drugs such as 5-aza-2′-deoxycytidine (5-AZAC) and Trichostatin A (TSA) showed efficacy in restoring ERβ expression in prostate cancer cells.
FVIIa has efficacy in restoring hemostasis.
While all these methods have proven their efficacy in restoring normal testosterone levels, their availability and affordability are not universal.
However, the data obtained from this multitude of studies resulted in promising but suboptimal efficacy in restoring functional skeletal muscle tissue.
However, because exercise programs have little efficacy in restoring muscle mass in old age, exercise should be started in young and middle age.
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Hence, the efficacy of repetitive ECV in restoring sinus rhythm was disappointing.
In contrast, although ZEB1 is considered a transcriptional repressor, we detected no significant changes for repressive histone marks H3K9me2 and H3K27me3 conferred by its cofactor LSD1 and PRC2 complex factors, explaining lower efficacy of their inhibitors in restoring the expression of miR-203.
That this activity has also translated to improved cognition in a short-term phase IIa human clinical trial of AD (Lannfelt et al., 2008; Faux et al., 2010) provides strong support for the efficacy of this compound in restoring normal brain function.
Even though its deficiency, which causes resistance to heparin, occurs at low frequency, antithrombin III should be assayed because of the serious consequences of circuit coagulation and the recognized value of antithrombin III replacement therapy in restoring the efficacy of heparin.
Based on their studies of the superior efficacy of 'behaviorally relevant' training in restoring lost functions in lower animals, Elbert et al. attribute the generally non-native-like outcomes of adult L2 learning to the fact that they just don't care very much about their accent.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com