The scale was created to assess a general sense of perceived self-efficacy, with the aim in mind of predicting ability to cope with daily demands as well as adaptation after experiencing all kinds of stressful life events.
19 When treating elderly populations, one should bear in mind that biofeedback efficacy may be limited by patients' declining physical or mental abilities.
50 If improvement is achieved at 3 months, 51 52 it must be borne in mind that maximal efficacy will not be seen before 6 months in many patients with most treatment strategies.
This means that studies to improve the safety as well as the efficacy of these treatments should keep in mind the role of the complement in the treatment [36], [44].
However, when a drug demonstrates better preventive efficacy on one pole than on the other, then it should be born in mind that such a differential efficacy may be overestimated for the reason given here, and we would warn against attempting to quantify such a differential efficacy.
Yet, keeping in mind limited specificity and efficacy and considerable toxicity of these agents, their effects need validation using classical ligands of the pathway of interest.
This is especially important in order to carefully select treatment options while keeping in mind the principles of maximum efficacy with minimal toxicity.
