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Because the current clinical evidence suggests comparability in terms of efficacy, finding the least costly of the two available treatment courses is important.
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This further demonstrates the value of the Mtm1−/y mouse as a model for XLMTM15,38,39,40 and supports future translation of tamoxifen efficacy findings from Mtm1−/y mice to XLMTM patients.
Safety and immunogenicity data from this study will be used to bridge 9vHPV vaccine efficacy findings in 16 26 year old women to 16 26 year old men.
Here, we report the efficacy findings of first 12 months of the extension (representing >18 or 15 months of total treatment).
However, it is increasingly recognized that observational studies can complement RCTs by supporting and extending efficacy findings from RCTs to real-world clinical practice, particularly across geographical populations.
Because it is not feasible to conduct HPV vaccine studies in younger adolescents who have not yet possibly been exposed to the HPV virus and who are not yet sexually active, Merck and the FDA agreed that efficacy findings in 16- to 26-year-olds can be applied to younger adolescents using immunogenicity data.
It will be a key test of the safety and efficacy findings of the CAPRISA 004 trial.
With clear differences in pathophysiology [5], [39] [41], safety and efficacy findings in other infections are difficult to extrapolate to severe malaria in humans although studies are ongoing to address this.
Several efficacy findings deserve further attention.
Efficacy findings confirm the value of BoNT-A as a treatment for CD symptoms.
Additionally, the dropout rates in studies need to be considered when interpreting the efficacy findings.
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CEO of Professional Science Editing for Scientists @ prosciediting.com