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The targeting feature and high oral bioavailability of MG-SME promised a good clinical efficacy, especially for immune diseases.
With the wider adoption of minimally invasive partial nephrectomy (PN), intermediate- and long-term outcomes data are needed to make firm conclusions about oncologic and functional efficacy, especially for robot-assisted PN (RPN).
Thus, it will be of great interest to test if chemical modifications of our cycE siRNA will improve its therapeutic efficacy, especially for systematic treatment in mice.
For the employment of antiangiogenic drugs, side effects have to be carefully weighed against efficacy, especially for patients with intermediate to good prognosis.
All these successes indicate that the VLP-based vaccine approach is an attractive alternative to replace or complement conventional inactivated virus vaccines or subunit vaccines with improved safety and efficacy, especially for children and the elderly.
They can decrease systemic toxicity and improve drug efficacy, especially for antibiotics, antifungals, and anticancer drugs [ 107, 118, 119].
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However, for benign lesions, piecemeal EMR has been shown to have comparable efficacy, especially when allowing for repeat treatment of recurrence, and with less morbidity.
Neoadjuvant chemosensitivity and endocrine sensitivity rates are increasingly accepted as surrogates for efficacy, especially if substantial impact can be demonstrated.
Schizophrenia has also been described as a syndrome involving large scale abnormalities of synaptic efficacy, especially within systems responsible for emotional learning and memory (Friston 1998).
The proliferation marker Ki67 is another marker of interest to be used as a surrogate marker for efficacy, especially with endocrine therapy [ 17, 32, 33].
Safety may be more important requirement for preclinical than efficacy especially in device field.
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CEO of Professional Science Editing for Scientists @ prosciediting.com