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Two approaches were employed to investigate potential modes of resistance: (i) mutagenesis and selection of cell lines resistant to the trypanosomal PDE inhibitor CpdA, followed by their characterization; and (ii) a whole-genome RNAi screen for drug efficacy determinants of CpdA.
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The identification of the area under the curve/time to MIC ratio as the major efficacy determinant may help tailor optimal dosage regimens in the near future [ 35].
Secondary outcome measures are: time until first return-to-work, total number of days of sickness benefit during follow-up; functional status; intensity of musculoskeletal pain; pain coping; and attitude, social influence and self-efficacy determinants.
Secondary outcomes are total number of days of sick leave during the follow-up, severity of common mental disorders, coping style, job content, and attitude, social influence, and self-efficacy determinants.
- Attitude, Social influence and self-Efficacy (ASE) determinants.
The effect of self-efficacy, environmental determinants, Portal use, and drop-out during follow-up on primary and secondary outcome measures will be evaluated for their potentially differential effects.
Mechanisms explaining the relationship between adolescent anxiety and parental control have been based on models that characterized the role of personal control and self-efficacy as determinants of anxiety [e.g., 26, 44].
To evaluate the effectiveness of workplace dietary modification interventions alone or in combination with nutrition education on employees' dietary behaviour, health status, self-efficacy, perceived health, determinants of food choice, nutrition knowledge, co-worker support, job satisfaction, economic cost and food-purchasing patterns.
As expected, based on our theoretical framework, perceived benefits and self-efficacy are important determinants of cholesterol, glucose, and HIV self-testing.
This may partially be explained by the lower prevalence of condom efficacy, an important determinant of consistent condom use among females.
Perceived benefits and perceived barriers, perceived social norms and self-efficacy are important determinants of behaviour and therefore also important change objectives.
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