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This percentage may increase with time as CPR efficacy declines.
Drug efficacy declines steadily in part because the converting enzyme, aromatic l-amino acid decarboxylase (AADC), is lost concomitant with substantia nigra atrophy.
However, if the length of the first drug cycle is too great, single-drug resistance reaches such high prevalence that therapeutic efficacy declines (Figure 8b).
Excluding the first week after IPT, the point estimate of protective efficacy declines with each successive week until efficacy approaches zero.
Research has shown that one application of PZP is often effective over multiple years, exhibiting yearly efficacy declines similar to that of 2 4 consecutive treatments (on Shackleford) [9], [58].
There is some indication that as resistance increases protective efficacy declines, as indicated by the negative rank correlations in all comparisons and there is a significant negative rank correlation between frequency of the triple dhfr genotype and 12 month protective efficacy −0.75 (p = 0.05).
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On some of these study sites the efficacy declined at the end of the expected ERP, often with good efficacy 2 weeks earlier.
Across the first four consecutive PZP applications, this efficacy declined from 97% to 87%, returning to 100% after five or more consecutive applications (see Fig. 4).
That rate of post treatment efficacy decline was substantially quicker than indicated by Lindsay.
In 25% of cases the efficacy declined during therapy, and the data were fitted assuming a fraction of cells resistant to treatment (Level II).
For Shiga toxin-producing strains of Escherichia coli, the efficacy of passive antibody is largely a function of the time of administration and the dose given, with antibody efficacy declining rapidly when administered after the second day of infection (83).
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