Sentence examples for efficacy curve from inspiring English sources
The upper part of the efficacy curve of the triptans is generally flat, the so-called ceiling effect; and none of the oral triptans, even in high doses, are as effective as subcutaneous sumatriptan, In contrast, AEs increases with increasing dose without a ceiling effect.
This arises because of the convex shape of the effectiveness vs initial efficacy curve (e.g. figure S1a c) which implies, following Jensen's inequality [26] that variation in the efficacy will increase the average effectiveness.
For many drugs dosing is limited by side effects/toxicity, so the bell-shaped part of the efficacy curve is never reached.
Other approaches proposed to estimate correlates of protection, such as the method of Chang and Kohberger [ 17, 39], the a b model [ 19], the vaccine efficacy curve method [ 3, 14, 16], and area-under-the-curve methods [ 21, 40] might be compared and reconciled with those suggested here.
The protective efficacy curves including children with and without parasitaemia together (figures 3, 4 & 5) remain of primary interest since they show the overall protection given that some children were infected when given IPT and some were not.
Compounds with class 1.1, 2.1, 1.2 or 2.2 (>50% efficacy) curves are considered active.
This would right-shift the efficacy curves (assuming the detergent doesn't disrupt the fibrils directly).
The pharmacological efficacy curves suggest that they provide a synergistic effect to block the relative fraction of vimentin+ cells.
Duwal et al. had estimated a Km of 29 ng/ml for TFV-DP formation by coupling PK model with mechanistic viral dynamics model and reproduced the efficacy curves of TFV monotherapy.
The efficacy curves calculated from equations (1.12) and (1.13) for equal-sized subnets, at subnet counts k ranging from 1 to N, are shown in Figure 6 for p = 1.5 and p = 10.
Due to this toxicity, the maximum tolerated dose is either sub-therapeutic or at the very bottom of the efficacy dose response curve [ 7].
