According to the WHO's recommendations, tests for treatment efficacy and cure should be the "highest research priority" in VL control [ 20].
Otherwise, clinicians would expose patients to an unacceptable risk of treatment failure, especially immunosuppressed and critically ill patients who rely almost completely on antibiotic efficacy for cure.
Though simple and accurate diagnostic tests are widely available to confirm VL, they are not suitable to monitor treatment efficacy and cure.
Retinoblastoma is a compelling disease model to illustrate the potential insights afforded in theory-informed approaches to improve outcomes that integrate public health and oncology perspectives, prioritizing both health service delivery and social efficacy for cure.
Although there are no large-scale studies to support treatment efficacy, parasitological cure is believed to occur in 60% to 85% of persons with acute infection who complete a full course of either drug.
Therefore, targeting these molecules offers the hope for not only an increased treatment efficacy and cure probability but also for an improved quality of life, an aspect that has a very high relevance for tumours that, like OS, mainly affect young people with long life expectancies.
The daily oral treatment of low drug doses allowed a higher cumulative dose to be delivered with improved antitumour efficacy (2/10 cured in a large cell lung cancer) and no evidence of toxicity.
Another study from Laos found that drugs obtained from pharmacies often have limited efficacy in curing STIs [ 23].
This different mode of action may be the cause of rifampicin's efficacy in curing F. candida of Wolbachia.
Assuming that the 24-month results will also fail to demonstrate efficacy in curing or ameliorating type 1 diabetes, how do we navigate the clinical complexities of stem cell trials for type 1 diabetes?
Here we have evaluated lower doses of KALSOME™10 (3.5 mg/kg single dose, 7.5 mg/kg single dose and 7.5 mg/kg double dose) for their efficacy in curing murine VL.
