The two RCTs were reported separately to the FDA to satisfy a requirement for two RCTs within a certain deadline in order to qualify for a 6-month patent extension, and the FDA correctly regarded both trials as separate studies that each failed to demonstrate efficacy and concluded, therefore, that no RCTs support antidepressant efficacy for sertraline.
In August 2010, The Economist praised Daniels' "reverence for restraint and efficacy" and concluded that "he is, in short, just the kind of man to relish fixing a broken state – or country".
A 3-week follow-up period for safety evaluation and efficacy recovery concluded the controlled study.
Equivalence of efficacy was concluded if the 95% CIs for treatment difference were within ±15% at week 30.
In summary, the available evidence does suggest that small differences in oestrogen suppression between the third-generation AIs do not lead to clinically significant differences in overall efficacy as concluded in my review (Sainsbury, 2004).
Cook et al.'s 2008 meta-analysis addressed efficacy, and concluded that, on average, Internet formats were equivalent to non-Internet formats in terms of learner satisfaction and changes in knowledge, skills and behaviour [ 8].
Although a Cochrane Collaboration Review [ 11] on physical training for cystic fibrosis reported inconsistency of study results in relation to efficacy, they concluded the anticipated benefits to lung function and feelings of self-esteem from engaging in physical activity were widely supported by health professionals who encourage exercise as part of an overall cystic fibrosis care package.
The second expert panel that evaluated the instrument theoretically according to the self-efficacy theory concluded that the instrument had adequate content to measure outcome and self-efficacy expectancy.
We further try to discern exactly what theory drives their presumption that language can have no cognitive efficacy, and conclude that their position is undermined by a wide range of considerations.
113 Regarding efficacy, the authors concluded that interferon-γ remains the agent with the best-proven efficacy, though its significant drawbacks (low percentage of responders, daily subcutaneous dosing, and high cost) preclude its widespread use.
