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It may be attributed to the weekly regimen that a higher dose of docetaxel could be determined as RD in our trial than in previous two trials; docetaxel administered once weekly has lower toxicity with comparable efficacy compared with the 3-weekly regimen (Schuette et al, 2005; Bria et al, 2006; Camps et al, 2006).
Tissue sections binding and in vitro anti-HBV activity assays demonstrated that the soluble Mu-IFN-CSP has comparable liver tissue binding capacity and higher anti-HBV efficacy compared with the native IFN-CSP.
As shown in Fig. 12c, it was found that the dual-drug nanoneedles had superior therapeutic efficacy compared with the other groups (P < 0.05).
Cytotoxicity analysis demonstrated that the cisplatin-crosslinked micelles loaded with DOX exhibited enhanced therapeutic efficacy compared with the DOX-loaded nanoparticles, free DOX, and free CDDP.
The increased in vivo efficacy compared with the in vitro bactericidal figures can potentially be explained by the generally observable immunostimulatory properties of antimicrobial peptides.
However, BIND Biosciences has shown a significant reduction of lung and tonsillar lesions using the combination of nanoparticles and chemotherapeutic drug with prostate-specific membrane antigen (PSMA) with greater efficacy compared with the drug alone, and at substantially lower doses.
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However, a significantly greater number of patients in the LY2140023 group discontinued from the study due to perceived lack of efficacy compared with those in the SOC group.
Thus, the longer isoform is only poorly (and in the case of UDP not at all) activated by uracil nucleotides, whereas the short isoform is activated with similar potencies, but slightly lower efficacies compared with the nucleotide receptors P2Y6 and P2Y14.
Though of low efficacy compared with levamisole, the use of A. indica seeds against gastrointestinal nematodes may be justified in some situations, depending on the nature and intensity of the helminth infections.
For studies that included three treatment groups, the group with the highest efficacy compared with control or the highest group from dose-ranging studies was included.
Rivastigmine demonstrated significant efficacy compared with placebo on the new subscale we termed working memory/memory, based on the range of SIB items encompassed in this subscale.
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