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Such protocols should ideally be evaluated in clinical trials to determine whether efficacy can be maintained while reducing the propensity for resistance.
Several phase III trials arer currently addressing this issue and are designed to investigated if efficacy can be maintained if radiotherapy in the sequential approach is combined with cetuximab in order to reduce toxicity.
Cohort II was initiated with a dose reduction of both drugs by 20% to investigate whether grade 1 4 side effects can be reduced, further dose adjustments can be avoided, but efficacy can be maintained.
Questions remain about the mechanism of sclerostin inhibition and how this is linked to osteocyte activity and feedback regulation in bone remodeling. 2 One clinical question is whether or not efficacy can be maintained after multiple doses of an anti-sclerostin monoclonal antibody (mAb).
Specifically, the aims are: Firstly, we intend to explore whether reminiscence therapy will significant improve the experiment group's depressive symptom in comparison with control group after six weeks therapy, and whether the efficacy can be maintained during three-month follow-up.
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21, 22 Vardenafil is a selective PDE-5 inhibitor, with a profile characterized by rapid onset of action, increased duration of erection, high rates of first-dose success and reliable efficacy that can be maintained with continued use.
The PDE-5 inhibitor, vardenafil, is characterized by a rapid onset of action, increased duration of erection, high rates of first-dose success and reliable efficacy that can be maintained with continued use.
In view of the low levels of circulating antibody in adolescence, there is uncertainty if the high vaccine efficacy against carriage can be maintained once infant vaccines become exposed to HBV via sexual routes.
To our knowledge, this is the first report showing that clinical and biological efficacy of HAART can be maintained in the long term in a hard-to-reach, mobile and highly stigmatised population in sub-Saharan Africa.
To determine whether the efficacy and safety achieved with monthly ranibizumab as treatment for diabetic macular edema (DME) can be maintained with less-than-monthly treatment.
If education and staff awareness can be maintained after the initial introduction, the MET system continues to increase in efficacy.
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