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The improved antimicrobial efficacy can be attributed to high surface area to volume ratios and unique chemical physical properties.
This lower efficacy can be attributed to a smaller average pore diameter as well as to diminished accessibility of the inner surface due to the coating of the polymer with polyvinylpyrrolidone. Adsorption of albumin, the most abundant plasma protein, was evaluated for the 5 vol% batch experiment.
If one trial compares drug A versus placebo and a second trial compares drug B versus placebo, it is incorrect to simply compare the absolute efficacy observed with drug A with that observed with drug B. Indeed, part of the absolute efficacy can be attributed to the drug, whereas another part is due to a placebo effect.
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The lack of significance for many of the efficacy endpoints can be attributed to several factors.
In addition to recognizing that many TBI clinical trials have not been optimally designed to detect potential efficacy, the failures can be attributed largely to the fact that most of the therapies investigated have been targeted toward an individual injury factor.
Successful performance of a skill or task can promote self-efficacy whereas repeated failures may lower self-efficacy; however, success can be attributed to an individual's own efforts and abilities.
A placebo effect has been observed in several cough clinical trials, and up to 85% of the efficacy of some cough medicines can be attributed to a placebo effect [ 25].
The enhanced efficacy of PTX/PLGA-PEG NPs can be attributed to their ability to penetrate within the brain tumor parenchyma, which facilitates improved particle and drug distribution to a greater proportion of the tumor mass.
Although these results are promising and suggest that targeted inhibition of eIF4E phosphorylation may be a valid therapeutic approach, it remains unclear to what extent the efficacy of MNK kinase inhibitors can be attributed to their ability to block other downstream phosphorylation targets critical for tumour growth and maintenance.
For example, it can support causality for the biological effects of a particular compound where the SAR and therapeutic mechanism of action in a clinical setting, as well as its efficacy in an animal disease model, can be attributed to specific inhibition of the enzyme target in vitro, a binding constant, a PDB structure and linked to its conversion to defined metabolites.
A criticism of our work is that we did not use an inactive placebo arm, so it is unclear how much of the documented efficacy (Tables 2, 3, and 4) can be attributed to a placebo response.
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CEO of Professional Science Editing for Scientists @ prosciediting.com