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Clinical efficacy can be achieved in some bacterial infections in which antimicrobials are suboptimal or even not prescribed.
Due to the above findings, pulmonary targeting such as inhaled delivery is believed to provide an advantage over systemic administration, where the same degree of efficacy can be achieved with lower systemic exposure.
The same protective efficacy can be achieved with lower doses of adenovirus vector allowing for a more extended use of each preparation and importantly minimizing toxicity from the vaccine vector.
However, the demonstration that equivalent efficacy can be achieved with fewer targeted courses appears to be an advantage of seasonally-targeted delivery in settings in which SP resistance is limited.
In addition, it remains to be shown whether sustained clinical efficacy can be achieved over time.
Reduced side effects, improved bioavailability, and efficacy can be achieved by local drug delivery.
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Here we demonstrate that substantial efficacy improvements can be achieved through further refinement of siRNA chemistry, optimizing the positioning of 2′-deoxy-2′-fluoro and 2′-O-methyl ribosugar modifications across both strands of the double-stranded siRNA duplex to enhance stability without compromising intrinsic RNAi activity.
Furthermore, data from the PSUMMIT trials suggest that the onset of action is slower with ustekinumab than TNFα inhibitors, although a similar efficacy rate can be achieved by 52 weeks.
However this strategy comes with its own challenges: it is not certain what degree of vaccine efficacy that can be achieved against an unknown future influenza strain, it may be difficult to achieve high levels of vaccination coverage, the pre-pandemic would need to be periodically renewed and re-administered.
The potential for rapid control depends on the efficacies that can be achieved for each intervention.
The platform predicts that most combinations of antipsychotics have a lower efficacy over what can be achieved by either one; negative pharmacodynamical interactions are prominent for aripiprazole added to risperidone, haloperidol, quetiapine and paliperidone.
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