Sentence examples for efficacy at lower doses from inspiring English sources

The combination therapy exhibited promising antimalarial efficacy at lower doses in comparison to the standard drug combination.

Increasing the dosing frequency also resulted in greater efficacy at lower doses of anti IL-6Rα (Supplementanti IL-6RαSupplementary

This improved efficacy at lower doses has been demonstrated, 8 and suggests that patients vary in their sensitivity to lanreotide Autogel.

Because the amount of FK506 delivered by FKDC is 10,000 fold less than the minimal effective dose of systemic FK506 to treat collagen induced arthritis, we hypothesized that efficacy at lower doses would translate to less toxicity.

Efficacy at lower doses than in CML is supported by in vitro data, indicating that the IC50 (drug concentration required to inhibit proliferation by 50%) for imatinib of PDGFR α-FIP1L1 is approximately 2-log lower than for BCR-ABL.

3 The drug is highly localised, so its analgesic efficacy is maximised at lower doses.

Despite this raft of largely positive findings, the transmission-blocking efficacy of primaquine, particularly at lower doses and in combination with an ACT, remains poorly understood (1, 12, 44, 45).

Afucosylated therapeutic antibodies with enhanced ADCC activity have been reported to possess greater efficacy in tumor growth inhibition at lower doses when compared to fucosylated therapeutic antibodies.

Similar disparities between physiologic or pharmacologic effects and GSNO levels have been noted in a study showing that efficacy of GSNO was evident at lower doses than those that caused increased BALF SNOs in experimental asthma [ 49].

Thus, our approach of combining NSC-124854 with TMZ shows promise in that NSC-124854 can overcome TMZ-induced resistance at lower doses and increase its efficacy against colorectal cancer.

Addition of DARA to both RDV and MPV significantly increased the treatment efficacy by almost doubling the lysis levels especially at lower doses of the cocktails.