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In the phase III AIM (Abatacept in Inadequate responders to Methotrexate (MTX)) trial, 1 abatacept demonstrated sustained clinical efficacy and consistent safety over 2 years of treatment.
Insulin glargine has demonstrated efficacy and consistent safety in numerous large randomized clinical studies, supporting its use as basal insulin therapy for the treatment of diabetes, in line with ADA/EASD recommendations.
Of note, the anti-proliferation effect of metformin was more robust under low and normal glucose conditions than under high glucose conditions (Fig 7C; Supplementary Fig S7B), indicating a modifying effect of nutrients on metformin efficacy and consistent with a previous report (Javeshghani et al, 2012).
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The authors of a study of FSWs and men who have sex with men in India argued that the positive association between social capital (group cohesion, social support and self-efficacy) and consistent condom use supported the development of interventions to increase social capital as an HIV prevention strategy [ 31].
Our findings suggest that residual inhibition is a highly variable phenomenon in its efficacy and consistency, and is most consistent where maskers are applied to regions of hearing loss, and are in keeping with prior research on residual inhibition (Roberts et al., 2008).
This effect may be important for its strong anti-tumor efficacy and is consistent with the current concept that inhibition of IGF-1R phosphorylation only decreases proliferation of tumor cells whereas in order to promote massive apoptosis and tumor regression the receptor needs to be downregulated.
Clinical efficacy and safety were consistent with prior studies.
Although no subject experienced an eruption in our study, the sufficient bowel cleansing efficacy and safety were consistent with our data.
This resulted in positive and consistent efficacy trends for several outcomes, but which lacked statistical significance.
Its efficacy has been high and consistent with the other echinocandins.
Overall, rituximab has exhibited very strong and consistent efficacy alone and in combination with virtually all of the chemotherapeutic agents used to treat B cell lymphomas.
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